A Note from our CEO: Alzheimer’s – A New Approach

Dear Community Members, Friends, Supporters, Former Patients, and Future Patients:

At NeuroCures™ our mission is to advance cures and innovate care that transforms the lives of patients with neurological conditions. In the last several months, one of the most devastating neurological diseases, Alzheimer’s, beat back two major efforts to tame it.

Alzheimer’s Studies Halted
We were saddened to hear that Biogen announced recently that they will stop Phase III studies of Aducanumab, a drug designed to slow the worsening of Alzheimer’s disease, due to lack of effectiveness. In January, Swiss pharmaceutical giant Roche and partner AC Immune halted two Phase III studies of their drug Crenezumab when an interim analysis by a committee of investigators showed those trials were likely to fail.

“This disappointing news confirms the complexity of treating Alzheimer’s disease and the need to further advance knowledge in neuroscience,” Biogen CEO Michel Vounatsos said. “We are incredibly grateful to all the Alzheimer’s disease patients, their families, and the investigators who participated in these trials and contributed greatly to this research.” Aducanumab targeted brain-destroying protein fragments—or “tangles” known as beta-amyloid—long thought to contribute to the buildup of plaque in the brain and deterioration of brain function.

Alzheimer’s Disease: A Complex Issue
Alzheimer’s kills more Americans than breast cancer and prostate cancer combined, according to the Alzheimer’s Association. With each failure, calls for different approaches grow louder. Citing the words of Winston Churchill, Alzheimer’s could represent “a riddle, wrapped in a mystery, inside an enigma.” The complexity of Alzheimer’s disease has a long history dating back to the turn of the last century.

In a clinical in southern France, a young physician was presented with a patient, Augusta Deter, who had a disease that stripped her of the most basic memories of her life. His name was Alois Alzheimer. Dr. Alzheimer, cared for Augusta until she passed away. Upon her death, he performed an autopsy and discovered strange tangles in Augusta’s brain. The same tangles had been cited in medical journals referencing a Parkinsonian brain. These early significant scientific references suggest the potential power of the Halo Effect™.

The Halo Effect™
Simply put, the Halo Effect™ states that all neurological diseases and deficits are connected. This connection could be at the molecular, cellular or genetic level. With advanced analytics, we can now begin to unlock the complexities of this deadly disease and offer potential solutions.

We Can Do More Together
Without research, there is no cure. Your generosity allows us to discover and apply breakthrough approaches for diseases across the neuroscience continuum. Join us!

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Thank you for helping us put breakthroughs within reach,

Teresa
Teresa M. Leezer, CEO,
NeuroCures™ Foundation

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